10th Quinquennial Conference on

Responses to DNA damage:

from molecule to  disease

Egmond aan Zee, The Netherlands, April 17-22, 2016



Provisional Program

Sunday April 17

13:00 – 17:00  Registration open                              

16:00               Opening ceremony

Chair: Leon Mullenders

16:10 – 17:00  The EMBO Keynote Lecture

Josef Jiricny (University of Zürich) “The Multifaceted Mismatch Repair”

17:00 – 17:50  Maria Jasin (Sloan Kettering Institute, New York) “Protecting the genome by homologous recombination”

17:50               Welcome drinks (in the Pub)

18:30               Dinner (Restaurant)

20:00 – 22:00  Poster viewing session I (3 parallel sessions: A-I: Base excision repair, B-I: Replication stress and Mismatch repair, C-I: DSB repair)          


Monday April 18


9:00                 Opening Plenary Session: 'Replication Stress'

                        Chair: Marcel Tijsterman

9:05 – 9:25      Thomas Kunkel (NIH, Research Triangle Park) “Studies of DNA replication infidelity in budding yeast”

9:25 – 9:45      Helle Ulrich (IMB, Mainz) “Dealing with DNA damage during replication”

9:45 – 10:05    Dana Branzei (IFOM, Milan) “Local regulation of recombination at sites of stalled replication”

10:05 – 10:25  Tony Carr (University of Sussex) “Mechanisms underpining replication-associated genome rearrangement”

10:25 – 10:40  Meindert Lamers  (MRC, Cambridge) “cryo-EM structures of the E. coli replicative DNA polymerase in DNA synthesis and DNA editing mode”


10:40 – 11:10 Coffee/tea Break


                        Continuation Plenary Session: 'Replication Stress'

                        Chair: Helle Ulrich

11:10 – 11:30  Johannes Walter (Harvard Medical School, Boston) “Mechanisms of vertebrate DNA cross-link repair”

11:30 – 11:50  Marco Foiani (IFOM, Milan) “ATR-mediated control of nuclear plasticity”

11:50 – 12:10  Andrea Pichler (Max Planck Institute) “SUMO rules”

12:10 – 12:25  Simone Sabbioneda (CNR , Pavia) “UBR5 protects DNA replication from DNA polymerase η toxicity mediated by ubiquitylated H2A”

12:25 – 12:40  Sasa Svikovic (MRC, Cambridge) “R-loops potentiate structured DNA-associated epigenetic instability”


12:40               Lunch

                        13:30 – 14:30  aDDRess Steering Committee and Management meeting (room 403)


14:30               Opening Plenary Session: 'Chromosome Stability'

                        Chair: Jessica Downs

14:35 – 14:55  Scott Keeney (Sloan Kettering Institute, New York) “Formation and processing of meiotic DNA breaks”

14:55 – 15:15  Matt Neale (University of Sussex) “Spatial patterning of meiotic recombination by DNA damage checkpoint kinases”

15:15 – 15:35  Jiri Lukas (University of Copenhagen) : Intrinsic molecular limits of genome surveillance”

15:35 – 15:55  Serena Nik-Zainal (Wellcome Trust, London) “Recent advances in mutational signatures identified in human somatic cells”

15:55 – 16-10  Bjoern Schwer (Harvard Medical School, USA) "Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells"

16:10 – 16:25  George Garinis  (IMBB-FORTH, Heraklion) “DNA damage and chromatin architecture during mammalian development”


16:25               Coffee/tea Break


16:55 -18:25    Poster discussion session I  (3 parallel sessions: A-I: Base excision repair, B-I: Replication stress and Mismatch repair, C-I: DSB repair)


18.30               dinner


20.00 - 22.00  Poster viewing session II (3 parallel sessions: A-II: Nucleotide excision repair-Annual IV aDDRess meeting, B-II: Replication stress and Translesion synthesis, C-II: DSB repair - HR)



Tuesday April 19


9.00                 Opening Plenary Session: 'Repair Mechanisms' 

                        Chair: Robert Fuchs

9:05 – 9:25      Roger Greenberg (University of Pennsylvania) “Mechanisms of ALTernative Telomere Recombination

9:25 – 9:45      Titia Sixma (NKI, Amsterdam) “Snapshots of DNA Mismatch Repair: Trapping Transient States”

9:45 – 10:00    Jean-Baptiste Charbonnier (I2BC, University Paris‐Saclay) “Pivotal roles of MutL homologs in mismatch repair and meiosis: insights from structural studies”

10:00 – 10:20  Sam Wilson (NIEHS, Research Triangle Park) “Step-to-step coordination in mammalian base excision repair”

10:20 – 10:35  Lars Schomacher (IMB, Mainz) “Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation


10:35 – 11:05 Coffee/tea Break


                        Continuation Plenary Session: 'Repair Mechanisms' 

                        Chair: Jan Hoeijmakers

11:05 – 11:25  Nicolas Thomä (FMI, Basel)The regulation of CRL4(DDB2) activity by the Cop9 Signalosome”

11:25 -11:45    Kaoru Sugasawa (Kobe University) “Molecular mechanisms regulating nucleotide excision repair in vivo”

11:45 – 12:05  Wei Yang (NIH/NIDDK, Bethesda) “ Tripartite DNA Lesion Recognition and Verification by XPC, TFIIH and XPA in Nucleotide Excision Repair”

12:05 – 12:25  Robert Fuchs (CRC, Marseille)Processing opposing lesions during NER triggers UV-mutagenesis in E. coli”

12:25 – 12:40  Simon Reed (Cardiff University) “How Global Genome–NER is organized in the yeast genome”


12:40               Lunch

                        13:30 – 14:30  aDDRess Fellows meeting (room 403)


14:30               Opening Plenary Session: 'Transcription Stress'

                        Chair: Wim Vermeulen

14:35 – 14:55 Jesper Svejstrup (Francis Crick Institute, London) “Transcription-associated genome instability”

14:55 – 15:15  Andrés Aguilera (Cabimer, Sevilla) “Role of Chromatin and the DNA damage response in transcription-associated genome instability”

15:15 – 15:35  Karlene Cimprich (Stanford University) “RNA Meets DNA: Mechanisms for Transcription-Associated Genome Instability”

15:35 – 15:55  Jurgen Marteijn (Erasmus MC, Rotterdam) “Transcription Coupled Nucleotide Excision repair, focusing on RNA Polymerase 2”

15:55 – 16:10  Julie Soutourina (CEA, Univ Paris-Sud) “Novel Mediator function connecting transcription and nucleotide excision DNA repair in eukaryotes”

16:10 -16:25    Chit Fang Cheok (IFOM, Milan) “p53 promotes genomic stability by preventing interference between transcription and replication”


16:25                Coffee/tea Break


16:55 -18:25    Poster discussion session II  (3 parallel sessions: A-II: Nucleotide excision repair-Annual IV aDDRess meeting, B-II: Replication stress and Translesion synthesis, C-II: DSB repair - HR)


18:30               dinner


20:00 - 2200    Poster viewing session III (3 parallel sessions: A-III: Nucleotide excision repair, B-III: Crosslink repair, C-III: DSB repair - NHEJ) 


Wednesday April 20


9.00                 Continuation Plenary Session:  'Repair Mechanisms'

                        Chair: Roland Kanaar

9:05 – 9:25      John Rouse (MRC, Dundee) “Control of DNA repair nucleases in health and disease”

9:25 – 9:45      Marcel Tijsterman (LUMC, Leiden) “Genome Maintenance and Diversification by Pol Theta-Mediated End Joining”

9:45 – 10:05    Jacqueline Jacobs (NKI, Amsterdam)Mechanisms underlying genome instability upon DNA repair at telomeres” (EMBO Young Investigator Lecture)

10:05 – 10:25  Claire Wyman (Erasmus MC, Rotterdam) “Tumor suppressors in action: Cellular and biochemical arrangements of BRCA2 - RAD51 complexes”

10:25 – 10:40  Julius Rabl (FMI, Basel) “Structural basis of BRCA1A function in DNA repair”


10:40 – 11:10 Coffee/tea Break


                          Continuation Plenary Session: 'Repair Mechanisms' 

                          Chair: Haico van Attikum

11:10 – 11:30 Niels Mailand (University of Copenhagen) “Ubiquitin-dependent responses to DNA double-strand breaks” (EMBO Young Investigator Lecture)

11:30 – 11:50  Steve Jackson (University of Cambridge) “Connections between ubiquitylation, deubiquitylation and DNA double-strand break repair”

11:50 – 12:10  Stephen West (Francis Crick Institute, London) “Cleavage of DNA by the structure-specific SMX tri-nuclease complex”

12:10 – 12:25  Puck Knipscheer (Hubrecht Institute, UMC Utrecht) “How does the Fanconi pathway promote unhooking of DNA interstrand crosslinks?”

12:25 – 12:40  Peter McHugh (WIMM, University of Oxford) “RPA activates the XPF-ERCC1 nuclease for interstrand crosslink repair” 


12:40              Lunch


Free afternoon


Thursday April 21


9:00                Opening Plenary Session: 'Chromatin stress'

                       Chair: Niels Mailand

9:05 – 9:25      Aaron Goodarzi (University of Calgary) “A novel role for CHD-class enzymes in the oxidative stress induced DNA damage response”

9:25 – 9:45      Evi Soutoglou (University of Strassbourg) “Temporal and spatial uncoupling of DNA Double Strand Break repair pathways within mammalian heterochromatin”

9:45 – 10:05    Daniel Durocher (University of Toronto) “How cells suppress homologous recombination in G1 cells”

10:05 – 10:25  Tim Humphrey (Oxford University) “Targeting histone H3K36me3-deficient cancers”

10:25 – 10:40  Chiara Balbo Pogliano (University of Zurich-Vetsuisse) “Regulation of global-genome DNA nucleotide excision repair by KMT2H histone methyltransferase”


10:40 – 11:10  Coffee/tea Break


                         Continuation Plenary Session: 'Chromatin stress'

                         Chair: Titia Sixma

11:10 – 11:30  Gaëlle Legube (CNRS, Toulouse) “Function of chromatin during DNA Double Strand Break repair” (EMBO Young Investigator Lecture)

11:30 – 11:50  Haico van Attikum (LUMC, Leiden) “Regulation of DNA repair in a chromatin context”

11:50 – 12.10  Jessica Downs (University of Sussex) “Chromatin remodelling complexes and the             maintenance of genome stability”

12:10 – 12:25  Dipanjan Chowdhury (Harvard Medical School, Boston) “DNA damage induced alternative polyadenylation of DNA repair gene transcripts influences the DNA damage response”

12:25 – 12:40  Jo Morris (University of Birmingham) “The BRCA1:BARD1 Ubiquitin ligase activity counters chromatin barriers to DNA resection”


12:40               Lunch


14:30               Opening Plenary Session: 'Clinical Aspects'

                        Chair: Pierre-Henri Gaillard

14:35 – 14:55  Peter McKinnon (St. Jude, Memphis) “New insights into base excision repair and the prevention of nervous system disease”

14:55 – 15:15  Yves Pommier (NCI, Bethesda) “DNA repair Alterations in Cancer Cell lines and Impact for precision Medicine”

15:15 – 15:35  KJ Patel (MRC, Cambridge) “The consequences and repair of endogenous DNA damage cause by natural reactive aldehydes”

15:35 – 15:55  Tomoo Ogi (Nagasaki University) “Genetics disorders associated with defects in transcription coupled nucleotide excision repair”

15:55 – 16:15  Keith Caldecott (University of Sussex)DNA strand break repair and human genetic disease” (EACR lecture)

16:15 – 16:30  Ross Chapman (University of Oxford) “53BP1 tunes p53-dependent transactivation events independently of the DNA damage response”


16:30               Coffee/tea Break


16:55 -18:25   Poster discussion session III  (3 parallel sessions: A-III: Nucleotide excision repair, B-III: Crosslink repair, C-III: DSB repair - NHEJ)


19:30               Conference dinner including poster prize ceremony                                           


Friday April 22


9:00                 Opening, Chair: Alan Lehman

9:05                 Keynote speaker – Nobel Prize Laureate in Chemistry 2015

             Tomas Lindahl (Clare Hall Laboratory) “The Intrinsic Fragility of DNA”

9:45                 Continuation Plenary Session: 'Clinical Aspects'

                        Chair: Alan Lehman

9:50 – 10:10    Kristijan Ramadan (Oxford University) “Chromatin-Associated Degradation in Human Diseases”

10:10 – 10:30  Andre Nussenzweig (NCI, Bethesda) “Synthetic viability in the absence of brca2”

10:30 – 10:45 


10:30 - 10.55 Coffee/tea Break


                        Continuation Plenary Session: 'Clinical Aspects'

                        Chair: Leon Mullenders

10:55 – 11:15 Jos Jonkers (NKI, Amsterdam) “Genetic dissection of tumor development, therapy response and resistance mechanisms in mouse models of BRCA1-deficient breast cancer”

11:15 – 11:35 Lenka Oplustil O'Connor (AstraZeneca, London) “A nanoparticle topoisomerase I inhibitor combination with DDR agents provides a novel approach to increasing therapeutic index”

11:35 – 11:50  Rob de Bruin (MRC, University College London) “Exploiting Cancer’s Addiction to Deregulated G1/S Transcription”

11:50               Keynote Speaker: Jan Hoeijmakers  (Erasmus MC, Rotterdam) “Maintaining nature’s perfection: DNA repair, cancer and longevity”

12:25                Closure

12:30                Lunch and departures (buses to airport)








Base Excision Repair



Olga Lavrik

Priscilla Cooper

Replication stress and Mismatch Repair


Peter Friedhoff

Joyce Lebbink

DSB Repair



Jo Morris

Philipp Oberdoerffer


Nucleotide Excision Repair – IV Annual aDDRess meeting


George Garinis

Orlando Schärer

Replication stress and Translesion Synthesis


Niels de Wind

Rick Wood

DSB Repair – HR



Alex Sartori

Vincent Dion


Nucleotide Excision Repair


Hannes Lans

Martijn Luijsterburg

Cross Link Repair


Puck Knipscheer

Peter McHugh

DSB Repair - NHEJ


Susan Lees-Miller

Marcel van Vugt


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Last revised: April 17, 2016