- MGC -        

The Centre is an initiative of the Erasmus Medical Center and the Leiden University Medical Center



The 25th MGC-Symposium

will be held Thursday, September 10, 2015 in Leiden, LUMC building 3


Symposia & Meetings:

Third International One Health Conference 2015 Prevention at the Source will be held in the city of Amsterdam, the Netherlands from 15-18 March 2015  ( Please observe the deadline of October 1st for abstract submission.

To simplify the search for an interesting meeting: .

This website gives an overview of conferences organized in all aspects of biology. It is open source so everybody can not only find but also add their meeting. It’s launched in April, 2012 and already contains over 400 conferences, a number that’s increasing every day.

All the added meetings are categorized so you can search both by keyword and category.

PCDI - Postdoc Career Development Initiative - is an organisation that aims at improving awareness of career planning and opportunities among postdocs, PhD students and their employers. We bring together scientists, universities and key players in the life science industry.

he 13th edition of  the PCDI Postdoc Retreat, targeting postdocs and final-stage PhD students in Life Sciences will be on 25 - 27 March 2015. This course is about professional and career development: ae you fully making use of your talents? What future matches your drives and skill set? What priorities do you need to set to maximise your potential? Read more...



MGC Course Programme

You can enrol now for the following courses:

Course  'Transgenesis, Gene Targeting and in vivo Imaging'

8 - 10 June, 2015, followed by a two-day symposium, 11-12 June, 2015

Faculteit der Sociale Wetenschappen, Pieter de la Court gebouw, 1A-01/1A-21
Wassenaarseweg 52, 2333 AK LEIDEN

Provisional program



The course will be build up in two parts: the first part is the three days course (8-10 June) en shortly after a two days symposium (11-12 June). Both parts are obliged to attend.

The course is organized for PhD students from the Medical Genetics Center Zuid-West Nederland (MGC) and the Oncology Graduate School Amsterdam (OOA). Three days of lectures and demonstrations given by experts in the field provide participants with an overview of the latest mouse genetic engineering and imaging technologies. Thereafter, participants will attend the popular biannual “Workshop on Innovative Mouse Models”, which brings together an international group of scientists interested in developing and exploiting mouse models to study fundamental developmental processes and to mimic human disease. Keynote speakers from leading laboratories present the latest developments on advanced genome alteration protocols, this year specifically focusing on the use of CRISPR/Cas9-assisted gene modification. Also novel imaging-technologies will be presented. The two-day workshop format combines keynote lectures and presentations of selected abstracts in order to encourage in-depth and unvarnished discussions of novel technologies. For course participants, meet-the-expert lunches will be organized on both days of the workshop.

We only have facilities to accommodate 30 participants. Selection is on a first-come, first-served basis.


Participation for free for all members of MGC and OOA Amsterdam (3 days course and two days symposia including one dinner)

Course fee for other personnel of the LUMC or Erasmus MC (3 days course and two days symposia including one dinner) is 150 euro

Course fee participants outside of these institutes (3 days course and two days symposia including one dinner) is 250 euro

Course specific cancellation terms

Deadline for registration is 22 May 2015. In case of cancellation after the deadline of registration or upon no show, participants from the MGC and OAA will be charged 50 euro; other participants have to pay the full price.

Mini-symposium CRISPR/Cas9

1.30 - 5.00 PM, 10 June, 2015

Faculteit der Sociale Wetenschappen, Pieter de la Court gebouw,
Wassenaarseweg 52, 2333 AK LEIDEN

Rectification: mini-symposium is cancelled for the moment. More information will follow in due time

Registration is open and free of costs for people from the MGC departments and the Oncology Graduate School, Amsterdam. For all other people please send an email to


Courses organized by MolMed


Biomedical English Writing Course for MSc and PhD-students

10 & 31 March, 21 April & 12 May.

Course of four sessions on writing a scientific article. Participants should ensure that they have time to prepare the various sections of a scientific paper or a lab work report, or to revise an already available manuscript. If your work has not advanced to this point, you should then participate in a later course.

For more information and registration:


Browsing Genes and Genomes with UCSC: Basic & Advanced

1 & 2 April 2015

This workshop will show how the UCSC Genome Browser is used to view multiple data sets at a variety of scales, from single-base to whole-genome. Attendees will learn browser navigation and an overview of the paradigm for data display. Selected datasets will be presented, such as UCSC Genes (a gateway to a large number of data sources) OMIM and Comparative Genomics tracks. Attendees will also learn about search, and about sharing information with others via Custom Tracks, the Sessions tool and the pdf-export function. Also presented will be the most recent tools, including bigBed and bigWig file formats, display of BAM files from high-throughput sequencing and data hubs.

Practical exercises will include Table Browser queries; using Custom Tracks; BLAT, a program for sequence alignment on the genome and the isPCR tool to test the uniqueness and predicted product from PCR (including on RNAs).

For more information and registration:


Research management for PhD-students

13 & 27 May 2015

Popular 2-days course on research management skills for PhD-students: - Time management; - Negotiating; - Yearly reviews (‘jaargesprekken’); and - Project management.

Full course attendance is necessary. There is place for 12 participants.

For more information and registration:


Internal (Erasmus MC) Course: A broad spectrum of NGS Applications in Molecular Medicine

12-13 May 2015

Next generation sequencing (NGS) has taken an enormous flight with many applications and different platforms. Also in the Erasmus MC, many NGS has been implemented in research projects and new diagnostic strategies. The MolMed graduate school aims to organize a course around NGS with the main goal to introduce its members to the technique, and especially to the types of platforms and the potential applications in research and diagnostics. End goals: to exchange knowledge and to raise awareness between all participants. PhD students, postdocs, senior scientists, including clinical researchers from Erasmus MC.

It will not be a hands-on course, but a showcase of scientists with mutual exchange of information and experience as much as possible. Content will contain all possible applications: Insights into who is doing what? What is possible, how does it work, do’s and don’ts, interpretation of data; both for basic researchers and clinical researchers

For more information and registration:


Course on R 

26-29 May 2015

This course is meant for PhD-students and other researchers who are just starting to program in R. This course will feature both practical sessions behind a computer and presentations. The course will begin with building the foundation of R as a programming language and move into the use of R as a statistical tool for analyzing data.

For more information and registration:


Workshop on Photoshop and Illustrator CS5 for PhD-students and other researchers

16 June 2015

Hands-on workshop on the Adobe programs Photoshop and Illustrator CS6. These programs are used for image enhancement and for drawing high quality graphs, tables and other figures. These are also freely available at the Erasmus MC on all Som-pc‘s. These can also be purchased at a very low price via

For more information and registration:


Gene expression data analysis using R: How to make sense out of your RNA-Seq/microarray data 

22-26 June 2015

Five days hands-on computer course for biological and clinical researchers whose research involves experiments that generate gene expression data. The course focuses on microarray and next-generation sequencing gene expression data, but some concepts may be applicable to other types of genomics data. Most of the speakers (and therefore examples) have a biomedical background. Software packages used are freeware, including the statistical software R, Bioconductor, Cytoscape and web tools. The total number of participants is limited to 40.

For more information and registration:


Courses organised by Boerhaave CME

On the 'Boerhaave CME (Continuing Medical Education)' website several courses for PhD students and other employees of the LUMC are announced:


- Introduction Genetic Epidemiology:  (once a year)

This intensive three day course will provide an introduction in genetic epidemiology. A large part of the day will be devoted to paper and computer exercises. Participants will gain practical experience by analyzing various data sets using SPSS or STATA.


- Design, Management & Analysis of Clinical trials: (once a year)

In this course, issues regarding the design, implementation and analysis of clinical trials will be considered. Topics include randomization and blinding, sample size calculations, flexible designs (interim analyses and stopping rules), cross-over trials, data monitoring and safety committees, data management and of course the statistical analyses based on the design chosen. We will also cover some aspects of reporting the design and outcome of clinical trials in scientific journals as well as Good Research Practice in general.

- Advanced Genetic Association Analysis: (once a year)

This up to date course in genetic association analysis includes now highly relevant topics such as the analysis of imputed genotypes in GWAS, genetic pathway analysis using GWAS data and the statistical analysis of rare variants detected by next generation sequencing. Participants have to bring their own laptop for practicals.

- Regression Analysis: (once a year)

This course considers both theoretical backgrounds and practical aspects of modeling data with regression models. The focus is on linear and logistic regression models, although other models, like Poisson models or non linear regression models for continuous data will also be discussed. All statistical methods are practiced, using SPSS.

- Using R in Data Analysis: (once a year)

R is an environment for statistical computing and graphics. Its flexibility, allied to the fact that it is open-source and free, have made it an ideal repository for implementations of statistical analysis methods, both classic and new. However, it has a steep learning curve, due partly to its using a command-line type of user interface, rather than the usual pull-down menus of most commonly used statistical packages such as SPSS. This 3-day course aims at helping researchers climb this curve, enabling them to perform basic data analysis and graphic displays at the end of the course, as well as giving a platform from which they can deepen their R knowledge later on if necessary.

- Dealing with Conflicting Demands: (once a year)

The life of a scientist presents many conflicting demands in any phase of the scientific career, but certainly in the last phase of a PhD study. The course ‘Dealing with Conflicting Demands’ builds on Dilemma Theory created in the 1980s by Prof. Charles Hampden-Turner (Cambridge, UK). Over the last decade the methodology has been further developed into a practical skill, used by staff of large and small corporations, including private and public research institutions. The skill to reconcile conflicting demands has proven key to being successful in a complex and competitive environment, such as your current and future working life as a scientist or any other professional environment.

- Repeated measurements: (once a year)

The course covers statistical methods to be used in the situation where one or more outcome variables are repeatedly measured in time on the same experimental unit.


- Basic methods and reasoning in biostatistics: (once a year)

The AIO courses in Biostatistics consist of two series: “A:basic” and “B:advanced”. Participants in part B should have followed part A or have acquired the skills trained in part A in another way. Part B as of 2009 consists of a series of separate courses, each dedicated to a specific subject.
Part A is a single one week course:
In this course we will cover basics of biostatistics and the participants will learn how to analyze problems in clinical research using SPSS. Subjects covered are among others: methodology of statistical analysis; causal inference; descriptive statistics; the principle of statistical estimation and testing; cross tabulation and chi-square test; Student t-test and the correspondence with non-parametric counterparts; simple regression and correlation; introduction to analysis of variance; interpretation of observational data; bias and confounding; interaction.


General information:

Download  the booklet with the teaching programme for PhD students, version 2014-2015

For new PhD students: Download the forms for Coaching Group and Teaching Plan

Download MGC bulletin 51 (September 2014),  MGC bulletin 50 (April 2014), 49 (September 2013)

Website of Leiden University on teaching for PhD students: English or Dutch. [Courses on Research management; Career counseling; Academic writing; Writing grants, proposals and beyond; Faster reading and Memory-improvement; Creative thinking; Academic presentation / Presentation of academic work; Orientation in policymaking; Orientation on Management]


The MGC Institutes

Het MGC secretariaat is gevestigd op

de afdeling Humane Genetica, LUMC, Leiden.

TEL 071-5269600; FAX 071-5268284  

Directie secretaris: Dr. M.J.M. Nivard 071-5269605  



De MGC instituten:

Instituut Celbiologie

Erasmus MC - Rotterdam

Postbus 2040, 3000 CA Rotterdam


hoofd: Prof.Dr. D. Huylebroeck (lid MGC bestuur)


Afd. Humane Genetica

Leiden Universitair Medisch Centrum

Postbus 9600, 2300 RC Leiden


hoofd: Prof.Dr. S.M. van der Maarel  (lid MGC bestuur)

Instituut Genetica

Erasmus MC - Rotterdam

Postbus 2040, 3000 CA Rotterdam


hoofd: Prof.Dr. J.H.J. Hoeijmakers (lid MGC bestuur)

Afd. Humane Genetica

Leids Universitair Medisch Centrum

Postbus 9600, 2300 RC Leiden


Prof.Dr. L.H.F. Mullenders (voorzitter MGC bestuur)

LACDR (Leiden/Amsterdam Center for Drug Research) - Toxicology group

Universiteit Leiden

P.O. Box 9502, 2300 RA Leiden


hoofd: Prof.Dr. B. van de Water (lid MGC bestuur)  

Instituut Klinische Genetica

Erasmus MC - Rotterdam

Postbus 2040, 3000 CA Rotterdam


hoofd: Prof.Dr. R.M.W. Hofstra (secretaris MGC bestuur)

Andere instituten/groepen binnen het MGC

Moleculaire Celbiologie (Prof. Dr. H.J. Tanke & Prof. Dr. A.K. Raap, Prof. Dr. J. Noordermeer & Dr. L. Fradkin, Prof. Dr. R. Hoeben, Prof. Dr. J.A. Maassen, Prof. Dr. P. ten Dijke)

Neurologie, groep neurogenetica, LUMC (Prof. Dr. R.A.C. Roos, Prof. Dr. J.J.G.M. Verschuuren, Prof. Dr. M.D. Ferrari)

Huid- en geslachtsziekten, groep erfelijke melanomen, LUMC (Prof. R. Willemze, Prof. Dr. W. Bergman, Dr. F. de Gruijl, Dr. N.A. Gruis)

Pathologie: moleculaire tumorpathologie, LUMC (Prof. Dr. P.C.W. Hogendoorn, Prof. J.V.M.G. Bovee, Prof. Dr. J. Morreau, Prof. Dr. P. Devilee)

Medische Statistiek, LUMC (Prof. Dr. T. Stijnen, Prof. Dr. P.E. Slagboom)

Anatomie en Embryologie, LUMC (Prof. Dr. C.L. Mummery)

Erasmus Optical Imaging Centre (OIC), Department of Pathology, Erasmus MC (Prof. Dr. A. B. Houtsmuller)

Kinderheelkunde, Ontwikkelingsbiologie groep, Erasmus MC (Prof. Dr. D. Tibboel)

Genetische Epidemiologie, Erasmus MC (Prof. Dr. C.M. van Duijn)

Afd. Voortplanting en Ontwikkeling, Erasmus MC (Prof. Dr. J.A. Grootegoed)

Forensische Moleculaire Biologie, Erasmus MC (Prof. Dr. M. Kayser)

Bioinformatica, Erasmus MC (Prof. Dr. P. van der Spek)

Biochemie, Erasmus MC (Prof. Dr. P. Verrijzer)


   [n.b. verbeteringen voor deze lijst gaarne doorgeven aan het secretariaat]




























Revised: May 08, 2015