- MGC -        

The Centre is an initiative of the Erasmus Medical Center and the Leiden University Medical Center

4 October 2013

25th-anniversary of the MGC

To conclude the 25th Anniversary Year we will organize a special edition of the MGC symposium on Friday, September 19, 2014 at Engels, Rotterdam


Symposia & Meetings:

Course program of 'Avans Hogeschool' can be found on their website:

The course 'ntroduction to Next Generation Sequencing; technologies, applications, and data analysis' will be organised from 1 - 4 April, 2014 at Avans Hogeschool, Lovensdijkstraat 61-63, Breda. For more information see

24 April 2014, Save the Date!! Erasmus OIC and AMIE present: Advanced imaging techniques from bench to bedside. see link. Attendance without costs.

CTO (Clinical and Translational Oncology) PhD course Development and Treatment of Breast and Colon Cancer - May 5-9, 2014, UMC Utrecht.  

Registration via the website of the PhD program Clinical & Translational Oncology.

To simplify the search for an interesting meeting: .

This website gives an overview of conferences organized in all aspects of biology. It is open source so everybody can not only find but also add their meeting. It’s launched in April, 2012 and already contains over 400 conferences, a number that’s increasing every day.

All the added meetings are categorized so you can search both by keyword and category.

PCDI - Postdoc Career Development Initiative - is an organisation that aims at improving awareness of career planning and opportunities among postdocs, PhD students and their employers. We bring together scientists, universities and key players in the life science industry.

The PCDI Postdoc Retreat for Life Sciences is only one month away. From 9 - 11 April 2014, early career researchers will step aside from their scientific duties and dedicate 3 days to reflect on their professional development. Find out how to shape your career and hear what can be done to increase your chances of success. Also this year the retreat programme includes a selection of interactive training workshops to support your professional development. Read more... Upon request PCDI has now extended the registration deadline to March 25th to allow researchers a bit more time to arrange funding. If you have not identified funding yet, do check again this page as more local contact persons have be added to the list of people who can support you in this process. We can still take a number of participants, register now to not miss out!

Would you like to know more about your career possibilities and the current labour market? Visit BCF Career Event, the largest career event for Life Sciences, Chemistry, Food and Pharma at Amsterdam RAI on May 14th. As a member of the PCDI community you can visit BCF Career Event for free! Use promotion code PCDI14 on the online registration form. PCDI will (be) present at the event as well. Click here for more information and to register.




MGC Course Programme

You can enrol now for the following courses:

Course 'Epigenetic Regulation'

April, 14-15, 2014, LUMC

Program 2014



The course aims to introduce students to epigenetic technologies by providing an overview of the state-of-the-art chromatin and gene regulation studies in The Netherlands. The course consists of lecture sessions in the morning and in the afternoon.

Some of the topics induced are: genome wide methylation profiling, genetic and epigenetic pathways in health and disease, transcription factors, chromatin remodelling, chromatin and the DNA damage response, X-inactivation and stem cells.

There is a minimum of 14 participants

The course is free for all PhD students, but also for post-docs and other personnel from Erasmus MC, LUMC and MGC. Participants from outside these organizations pay € 150 for this course.


Course 'Next Generation Sequencing data analysis'

8th edition scheduled for August / September 2014

Program previous edition (2013)

Pre Registratie NGS

Course 'Development, Stem Cells and Disease'


course will be given in the form of a series of seminars

The aim of this course is to discuss recent advances in our knowledge concerning the molecular and cellular mechanisms controlling the development of vertebrate embryos.

Stem cells: embryonic; somatic; cancer; plant

Patterning: fluorescence tagging; axis formation; face and limbs

Gene regulation: X-chromosome inactivation, tissue specific regulation

Signalling: Hedgehog, TGFβ, Notch, Wnt signalling.

Organ systems: Lung development; sex determination; muscle development; hematopoiesis; neuronal development; Axon-Glia interaction; Axon pathfinding.


Courses organized by MolMed


Research management for PhD-students

3 & 17 April 2014

Popular 2-days course on research management skills for PhD-students: - Time management; - Negotiating; - Yearly reviews (‘jaargesprekken’); and - Project management.

Full course attendance is necessary. There is place for 12 participants.

For more information and registration:


An Introduction to the analysis of the next-generation sequencing (NGS) data

14 - 18 April 2014

This course provides an introduction to working with Next-Generation Sequencing (NGS) data. It targets individuals who have access to NGS data and want to learn how to work with this data and what the possibilities and limitations of NGS are. Lectures will be complemented with practical sessions in which the student will gain hands-on experience with various tools and techniques. A vast array of subjects will be covered during this course.

For more information and the course program:

This course is organized in collaboration with Nihes, who handles the registrations.

For registration:


Internal (Erasmus MC) Course: A broad spectrum of NGS Applications in Molecular Medicine

23-24 April 2014

(Program attached)

This is a novel course that introduces NGS techniques and, in particular, the platforms types and potential applications in research and in diagnostics.  It will be a showcase of different techniques. The aim is to stimulate mutual exchange of information and experience between all those attending. This course is meant for PhD students, postdocs, and senior scientists, including clinical researchers from Erasmus MC.

For more information, detailed program, and registration:


Workshop on Microsoft Excel 2010: Advanced

24 April 2014

This course is meant for those desiring to gain advanced skill sets necessary for calculating data using functions and formulas, using PivotTables for analyzing data, and customizing workbooks.

For participating the Advanced Workshop it is necessary to have taken the basic Excel Workshop, or to be well acquainted with all the topics of the basic Excel Workshop.

For more information and registration:


Workshop on NCBI & other open source software

12-15 May 2014

This is a novel hands-on computer course on several open source tools for life sciences, including NCBI. This course is organized by the bioinformatics dept., together with the school.

For more information on the different tools, and registration:


Course on R

19 - 22 May 2014

R ( has become the 'lingua franca' of data analysis and statistical computing. Its great success is attributed to its free availability and the capability for a wide range of analysis and graphics. This course, set-up and given by two experienced R users, is meant for PhD-students and other researchers who are just starting to program in R. During this course you'll learn to apply basic statistical methods and analyses using R.

Full program and registration:


Workshop on Microsoft Access 2010: Advanced

5 June 2014

The advanced course is for the individual whose responsibilities include creating new databases, tables, and relationships, as well as working with and revising advanced-level queries, forms, and reports. You will design and create a new Access database; improve queries, create advanced forms, and reports; and integrate Access 2010 with other applications.

For participating the Advanced Workshop it is necessary to have taken the basic Access Workshop, or to be well acquainted with all the topics of the basic Access Workshop.

Full program and registration:


Analysis of microarray and RNA Seq expression data using R/BioC and web tools

30 June – 4 July 2014

Five days hands-on computer course for biological and clinical researchers whose research involves experiments that generate gene expression data. The course focuses on microarray data, but some concepts may be applicable to next-generation sequencing gene expression data, or other types of genomics data measured on microarrays. Most of the speakers (and therefore examples) have a biomedical background. Software packages used are mostly freeware, including the statistical software R, Bioconductor, Cytoscape and web tools. The only commercial tool used is Spotfire. The total number of participants is limited to 40.

More information, detailed course program,  and registration:


Virology Course and Symposium

30 June – 2 July 2014

This course provides a comprehensive introduction into the field of fundamental and translational virus research. This course is organised together with the dept. of Virology and is meant for PhD students, postdocs and medical microbiologists.

The third day of this course: 2 July, will be a special Symposium at WTC, Rotterdam, entitled: 'Virology in the last 4 decades: Breakthroughs and Benefits'.

For more information, detailed course program, and registration:


Translational Imaging Workshop by AMIE: From mouse to man

11 – 14 November 2014

The programme Applied Molecular Imaging at Erasmus MC (AMIE) provides a platform for scientists interested in imaging technology and molecular imaging in general. The aim of this 4-day workshop is to give a broad introduction into preclinical and translational Molecular Imaging techniques and their applications in biology and medicine. The Workshop features demos of different techniques and the possibility to perform an experiment on one of the techniques.

This workshop is designed for PhD-students and researchers in one of the Erasmus Postgraduate Schools, but PhD students and researchers from other universities are also welcome.

More information and registration:


SNP Course XI: SNPs and Human Diseases

17 - 21 November 2014

Annual five-days course on SNP and Complex Diseases, including hands-on computer practicals.

For participation, basic knowledge of the central molecular biological is required. This can be obtained at the basic human Genetics course: Genetics for dummies.

For more information and registration:


Courses organised by Boerhaave CME

On the 'Boerhaave CME (Continuing Medical Education)' website several courses for PhD students and other employees of the LUMC are announced:


- Introduction Genetic Epidemiology:  (once a year)

This intensive three day course will provide an introduction in genetic epidemiology. A large part of the day will be devoted to paper and computer exercises. Participants will gain practical experience by analyzing various data sets using SPSS or STATA.


- Design, Management & Analysis of Clinical trials: (once a year)

In this course, issues regarding the design, implementation and analysis of clinical trials will be considered. Topics include randomization and blinding, sample size calculations, flexible designs (interim analyses and stopping rules), cross-over trials, data monitoring and safety committees, data management and of course the statistical analyses based on the design chosen. We will also cover some aspects of reporting the design and outcome of clinical trials in scientific journals as well as Good Research Practice in general.

- Advanced Genetic Association Analysis: (once a year)

This up to date course in genetic association analysis includes now highly relevant topics such as the analysis of imputed genotypes in GWAS, genetic pathway analysis using GWAS data and the statistical analysis of rare variants detected by next generation sequencing. Participants have to bring their own laptop for practicals.

- Regression Analysis: (once a year)

This course considers both theoretical backgrounds and practical aspects of modeling data with regression models. The focus is on linear and logistic regression models, although other models, like Poisson models or non linear regression models for continuous data will also be discussed. All statistical methods are practiced, using SPSS.

- Using R in Data Analysis: (once a year)

R is an environment for statistical computing and graphics. Its flexibility, allied to the fact that it is open-source and free, have made it an ideal repository for implementations of statistical analysis methods, both classic and new. However, it has a steep learning curve, due partly to its using a command-line type of user interface, rather than the usual pull-down menus of most commonly used statistical packages such as SPSS. This 3-day course aims at helping researchers climb this curve, enabling them to perform basic data analysis and graphic displays at the end of the course, as well as giving a platform from which they can deepen their R knowledge later on if necessary.

- Dealing with Conflicting Demands: (once a year)

The life of a scientist presents many conflicting demands in any phase of the scientific career, but certainly in the last phase of a PhD study. The course ‘Dealing with Conflicting Demands’ builds on Dilemma Theory created in the 1980s by Prof. Charles Hampden-Turner (Cambridge, UK). Over the last decade the methodology has been further developed into a practical skill, used by staff of large and small corporations, including private and public research institutions. The skill to reconcile conflicting demands has proven key to being successful in a complex and competitive environment, such as your current and future working life as a scientist or any other professional environment.

- Repeated measurements: (once a year)

The course covers statistical methods to be used in the situation where one or more outcome variables are repeatedly measured in time on the same experimental unit.


- Basic methods and reasoning in biostatistics: (once a year)

The AIO courses in Biostatistics consist of two series: “A:basic” and “B:advanced”. Participants in part B should have followed part A or have acquired the skills trained in part A in another way. Part B as of 2009 consists of a series of separate courses, each dedicated to a specific subject.
Part A is a single one week course:
In this course we will cover basics of biostatistics and the participants will learn how to analyze problems in clinical research using SPSS. Subjects covered are among others: methodology of statistical analysis; causal inference; descriptive statistics; the principle of statistical estimation and testing; cross tabulation and chi-square test; Student t-test and the correspondence with non-parametric counterparts; simple regression and correlation; introduction to analysis of variance; interpretation of observational data; bias and confounding; interaction.


General information:

Download the booklet with the teaching programme for PhD students, version 2013-2014

For new PhD students: Download the forms for Coaching Group and Teaching Plan

Download MGC bulletin 49 (September 2013), MGC bulletin 48 (March 2013)

Website of Leiden University on teaching for PhD students: English or Dutch. [Courses on Research management; Career counseling; Academic writing; Writing grants, proposals and beyond; Faster reading and Memory-improvement; Creative thinking; Academic presentation / Presentation of academic work; Orientation in policymaking; Orientation on Management]


The MGC Institutes

Het MGC secretariaat is gevestigd op

de afdeling Toxicogenetica te Leiden.

TEL 071-5269600; FAX 071-5268284  

Directie secretaris: Dr. M.J.M. Nivard 071-5269605  



De MGC instituten:

Instituut Celbiologie

Erasmus MC - Rotterdam

Postbus 2040, 3000 CA Rotterdam


hoofd: Prof.Dr. F.G. Grosveld  (voorzitter MGC bestuur)


Centrum voor Humane en Klinische Genetica

Leiden Universitair Medisch Centrum

Postbus 9600, 2300 RC Leiden


hoofd: Prof.Dr. S.M. van der Maarel 

Prof. Dr. G.J.B. van Ommen (secretaris MGC bestuur)

Instituut Genetica

Erasmus MC - Rotterdam

Postbus 2040, 3000 CA Rotterdam


hoofd: Prof.Dr. J.H.J. Hoeijmakers (lid MGC bestuur)

Afd. Toxicogenetica

Leids Universitair Medisch Centrum

Postbus 9600, 2300 RC Leiden


hoofd: Prof.Dr. L.H.F. Mullenders (lid MGC bestuur)  

LACDR (Leiden/Amsterdam Center for Drug Research) - Toxicology group

Universiteit Leiden

P.O. Box 9502, 2300 RA Leiden


hoofd: Prof.Dr. B. van de Water (lid MGC bestuur)  

Instituut Klinische Genetica

Erasmus MC - Rotterdam

Postbus 2040, 3000 CA Rotterdam


hoofd: Prof.Dr. R.M.W. Hofstra (lid MGC bestuur)

Andere instituten/groepen binnen het MGC

Moleculaire Celbiologie (Prof. Dr. H.J. Tanke & Prof. Dr. A.K. Raap, Prof. Dr. J. Noordermeer & Dr. L. Fradkin, Prof. Dr. R. Hoeben, Prof. Dr. J.A. Maassen, Prof. Dr. P. ten Dijke)

Neurologie, groep neurogenetica, LUMC (Prof. Dr. R.A.C. Roos, Prof. Dr. J.J.G.M. Verschuuren, Prof. Dr. M.D. Ferrari)

Huid- en geslachtsziekten, groep erfelijke melanomen, LUMC (Prof. R. Willemze, Prof. Dr. W. Bergman, Dr. F. de Gruijl, Dr. N.A. Gruis)

Pathologie: moleculaire tumorpathologie, LUMC (Prof. Dr. P.C.W. Hogendoorn, Prof. J.V.M.G. Bovee, Prof. Dr. J. Morreau, Prof. Dr. P. Devilee)

Medische Statistiek, LUMC (Prof. Dr. T. Stijnen, Prof. Dr. P.E. Slagboom)

Anatomie en Embryologie, LUMC (Prof. Dr. C.L. Mummery)

Instituut Pathologie, groep Fodde, Erasmus MC (Prof. Dr. R. Fodde)

Erasmus Optical Imaging Centre (OIC), Department of Pathology, Erasmus MC (Prof. Dr. A. B. Houtsmuller)

Kinderheelkunde, Ontwikkelingsbiologie groep, Erasmus MC (Prof. Dr. D. Tibboel)

Genetische Epidemiologie, Erasmus MC (Prof. Dr. C.M. van Duijn)

Afd. Voortplanting en Ontwikkeling, Erasmus MC (Prof. Dr. J.A. Grootegoed)

Forensische Moleculaire Biologie, Erasmus MC (Prof. Dr. M. Kayser)

Bioinformatica, Erasmus MC (Prof. Dr. P. van der Spek)

Biochemie, Erasmus MC (Prof. Dr. P. Verrijzer)


   [n.b. verbeteringen voor deze lijst gaarne doorgeven aan het secretariaat]




























Revised: April 07, 2014