- MGC -        

The Centre is an initiative of the Erasmus Medical Center and the Leiden University Medical Center



Symposia & Meetings:

Nuclear Receptor Research Network meeting, 03-12-2015, Leiden

On December 3rd 2015, the Nuclear Receptor Research Network (NRRN) is organising the 8th Benelux Nuclear Receptor meeting at the Boerhaave museum in Leiden. The latest advances on nuclear receptor (NR) research will be discussed.

Registration deadline: November 1st.

For more information visit the website

To simplify the search for an interesting meeting: .

This website gives an overview of conferences organized in all aspects of biology. It is open source so everybody can not only find but also add their meeting. It’s launched in April, 2012 and already contains over 400 conferences, a number that’s increasing every day.

All the added meetings are categorized so you can search both by keyword and category.

 Titel: Flowcytometrie, van kalibratie tot applicatie, Datum: 10, 17 en 24 november 2015 (om 16.00-18.30), Locatie: Erasmus MC, Rotterdam, Kosten: €600,- (inclusief theoretisch naslagwerk), Website:

The Clinical and Translational Oncology (CTO) PhD program of the Utrecht Graduate School of Life Sciences (UMC Utrecht) organizes a One-day course Neuro-oncology – 8 December 2015. For registration and further information please visit the CTO website:

PCDI - Postdoc Career Development Initiative - is an organisation that aims at improving awareness of career planning and opportunities among postdocs, PhD students and their employers. We bring together scientists, universities and key players in the life science industry.

From 28 - 30 October PCDI organises the 14th edition of the PCDI Postdoc Retreat. At this course you will literally be taken out of your academic environment to spend dedicated time to think about your future, improve your skills and learn about the many aspects that contribute to success. The programme offers a combination of lectures by inspiring PhD graduates, training sessions, a forum discussion with opinion leaders and energising networking sessions, all aimed at broad career and professional development. This edition especially targets postdocs and final stage PhD students in Science, Technology, Engineering, Maths (STEM). For more information about the course read on



MGC Course Programme

You can enrol now for the following courses:

Course 'Veilig werken in Laboratoriuma'

16 November 2015, LUMC

Building 3, V3-18

Program 2015 (Dutch version)

Registration is closed - Course is fully booked

This course is mandatory for all PhD students working within the MGC. This edition of the course will be in Dutch; the English version,  'Safely working in laboratory', is expected to be given in spring 2016.

Course 'Technology Facilities'

18 - 21 January, 2016, LUMC

Program  from 2014 edition


The course will deal with four topics:

Day 1 - Genomics and Transcriptomics (LUMC, building 1, lecture room 2)

     Organizers: Dr. W. van IJcken, Erasmus MC, Rotterdam and Dr. H.P.J. Buermans, LUMC, Leiden

Day 2 - Proteomics (LUMC, building 1, lecture room 4)

    Organizers: Dr. J. Demmers, Erasmus MC, Rotterdam and Dr. P. Hensbergen, LUMC, Leiden

Day 3 – Imaging (LUMC, building 1, lecture room 2)

     - Live cell imaging

    Organizers: Prof. Dr. A. B. Houtsmuller and Dr. W.A. van Cappellen, Erasmus MC, Rotterdam

     - In vivo imaging – whole body optical imaging and MRI technology

    Organizer: Prof. Dr. C. Lowik, Erasmus MC, Rotterdam

Day 4 - Metabolomics (new topic in this course!!) (LUMC, building 1, lecture room 3)

    Organizers: Prof. Dr. T. Hankemeier and L. Beijersbergen, LACDR, Div of Analytical Biosciences, Leiden University 


The course is meant for PhD students, technicians, or post-docs who are not familiar with the different topics, but encountered (or may encounter) problems in their research project that can be addressed by using techniques as mentioned above and therefore need some know how about the way they can perform specific experiments. 

Not all expertise for specific techniques is always available in your department. The course will inform you about the possibilities of the different techniques and who the experts are within the MGC or outside it.

One can subscribe also for only one, two or three days.

There is a minimum of 20 and a maximum of 50 places.


The course is free of charge for all personnel from MGC. Participants from outside this organisation pay €250 for including lunches. Registration costs for a single day is €100 for every extra day 50 eurois will be charged.

Course 'Genome Maintenance and Cancer'

March 21 -22, 2016, LUMC

Program 2014 edition

Registration in due time

Preservation of genetic information (DNA) is of prime importance to all living systems. The aim of the course is to familiarize participants with the mechanisms that are involved in maintaining genome stability. In the environment humans are exposed to chemical agents and radiation, which threaten the integrity of the genetic material leading to risks for the induction of cancer and congenital malformation. To withstand the harmful effects of DNA damage and to maintain genome integrity, cells are equipped with an intricate network of DNA damage response pathways. Key players in these processes are protein complexes involved in DNA replication, DNA repair and chromosome segregation as well as regulators of the cell cycle and cell death.

This course will provide an up to date insight in the chain of reactions from exposure to the ultimate consequences. Lectures will deal with the basic principles of several cell biological aspects such as DNA damage formation, signalling pathways, DNA repair and mutation formation.  A few lectures will deal with more applied research.


There is a minimum of 14 and a maximum of 50 places.


The course is free of charge for all personnel of MGC associated institutes. Participants from outside these organizations pay € 150 for this course.

Course 'Epigenetic Regulation'

May 2-3, 2016, LUMC

Program 2014 edition

Registration in due time 

The course aims to introduce students to epigenetic technologies by providing an overview of the state-of-the-art chromatin and gene regulation studies in The Netherlands. The course consists of lecture sessions in the morning and in the afternoon.

Some of the topics induced are: genome wide methylation profiling, genetic and epigenetic pathways in health and disease, transcription factors, chromatin remodelling, chromatin and the DNA damage response, X-inactivation and stem cells.

There is a minimum of 14 and a maximum of 100 places.


The course is free of charge for all personnel of MGC associated institutes. Participants from outside these organizations pay € 150 for this course.

Courses organized by MolMed


SNP Course XII: SNPs and Human Diseases

16-20 November 2015

The analysis of DNA variations, including Single Nucleotide Polymorphisms (SNPs), is a standard research approach to understand causes of disease, in particular the so-called “complex” diseases such as diabetes, osteoporosis, cancer, Alzheimer disease, etc. The field is changing fast with large scale projects (Human genome, dbSNP, HapMap, 1000genomes, ENCODE) and novel technology being continuously introduced, including Next Generation Sequencing.

Aim: The aim of this course is to give a broad introduction in SNP techniques and applications. The course is primarily organized for PhD students and postdocs of the Erasmus Postgraduate School Molecular Medicine, Nihes, MGC and other research schools. Other participants, e.g., scientists, students, and technicians from other universities in- and outside Netherlands are also welcome.

For more information and registration:


Translational Imaging Workshop by AMIE: From mouse to man

24-27 November 2015

The aim of this 4-day workshop is to give a broad introduction into preclinical and translational Molecular Imaging techniques and their applications in biology and medicine. The program also has demos and gives the possibility to work with one the different techniques: PET-SPECT, CT, MRI, Optical Imaging, and Ultrasound.

This workshop is designed for PhD students and researchers in one of the Erasmus Postgraduate Schools; PhD students and researchers from other universities are also welcome.

For more information and registration:


MS Excel 2010 Workshops (Basic & Advanced)

8 & 10 December 2015

One-day practical workshops on the use of Excel for scientific research, including how to use Excel for complex formulas and how to work with the information from an Access database.

For more information about these courses and for registration:


Survival Analysis Course

17-18 December 2015

Two day course on medical statistics for MDs, PhD students and MSc students. The first day consists of a brief introduction to statistics, the second day is on survival analysis specifically.

Aim of the course: Understanding (some of) the essentials of statistical theory, choosing the appropriate statistical test given the research question and data, performing the corresponding statistical analysis and interpreting the resulting statistical output.

The program consists of four parts: Introduction to basic statistics; Introduction to survival analysis; Survival rates and group differences; and Predicting survival rates and more complicated topics.

For more information and registration:


Course on R

4-8 January 2016

Hands-on introduction course of four days given by dr. Mc Clellan and dr. Brand on R, the 'lingua franca' of data analysis and statistical computing. Its great success is attributed to its free availability and the capability for a wide range of analysis and graphics. ( This course is meant for PhD-students and other researchers who are just starting to program in R. This course will feature both practical sessions behind a computer and presentations. The course will begin with building the foundation of R as a programming language and move into the use of R as a statistical tool for analyzing data.

For more information and registration:



Course and Workshop Basic and Translational Endocrinology

24-28 October 2016

The aim of this course and workshop is to offer a comprehensive, interactive introduction to the field of basic and translational Endocrinology, including the paediatric aspects. Its target audience are PhD students working in this field, who like to gain in-depth knowledge, but also MDs and others wo are interested, are welcome to register.

For more information and registration:


Courses organised by Boerhaave CME

On the 'Boerhaave CME (Continuing Medical Education)' website several courses for PhD students and other employees of the LUMC are announced:


- Introduction Genetic Epidemiology:  (once a year)

This intensive three day course will provide an introduction in genetic epidemiology. A large part of the day will be devoted to paper and computer exercises. Participants will gain practical experience by analyzing various data sets using SPSS or STATA.


- Design, Management & Analysis of Clinical trials: (once a year)

In this course, issues regarding the design, implementation and analysis of clinical trials will be considered. Topics include randomization and blinding, sample size calculations, flexible designs (interim analyses and stopping rules), cross-over trials, data monitoring and safety committees, data management and of course the statistical analyses based on the design chosen. We will also cover some aspects of reporting the design and outcome of clinical trials in scientific journals as well as Good Research Practice in general.

- Advanced Genetic Association Analysis: (once a year)

This up to date course in genetic association analysis includes now highly relevant topics such as the analysis of imputed genotypes in GWAS, genetic pathway analysis using GWAS data and the statistical analysis of rare variants detected by next generation sequencing. Participants have to bring their own laptop for practicals.

- Regression Analysis: (once a year)

This course considers both theoretical backgrounds and practical aspects of modeling data with regression models. The focus is on linear and logistic regression models, although other models, like Poisson models or non linear regression models for continuous data will also be discussed. All statistical methods are practiced, using SPSS.

- Using R in Data Analysis: (once a year)

R is an environment for statistical computing and graphics. Its flexibility, allied to the fact that it is open-source and free, have made it an ideal repository for implementations of statistical analysis methods, both classic and new. However, it has a steep learning curve, due partly to its using a command-line type of user interface, rather than the usual pull-down menus of most commonly used statistical packages such as SPSS. This 3-day course aims at helping researchers climb this curve, enabling them to perform basic data analysis and graphic displays at the end of the course, as well as giving a platform from which they can deepen their R knowledge later on if necessary.

- Dealing with Conflicting Demands: (once a year)

The life of a scientist presents many conflicting demands in any phase of the scientific career, but certainly in the last phase of a PhD study. The course ‘Dealing with Conflicting Demands’ builds on Dilemma Theory created in the 1980s by Prof. Charles Hampden-Turner (Cambridge, UK). Over the last decade the methodology has been further developed into a practical skill, used by staff of large and small corporations, including private and public research institutions. The skill to reconcile conflicting demands has proven key to being successful in a complex and competitive environment, such as your current and future working life as a scientist or any other professional environment.

- Repeated measurements: (once a year)

The course covers statistical methods to be used in the situation where one or more outcome variables are repeatedly measured in time on the same experimental unit.


- Basic methods and reasoning in biostatistics: (once a year)

The AIO courses in Biostatistics consist of two series: “A:basic” and “B:advanced”. Participants in part B should have followed part A or have acquired the skills trained in part A in another way. Part B as of 2009 consists of a series of separate courses, each dedicated to a specific subject.
Part A is a single one week course:
In this course we will cover basics of biostatistics and the participants will learn how to analyze problems in clinical research using SPSS. Subjects covered are among others: methodology of statistical analysis; causal inference; descriptive statistics; the principle of statistical estimation and testing; cross tabulation and chi-square test; Student t-test and the correspondence with non-parametric counterparts; simple regression and correlation; introduction to analysis of variance; interpretation of observational data; bias and confounding; interaction.


General information:

Download the booklet with the teaching programme for PhD students, version 2015-2016

For new PhD students: Download the forms for Coaching Group and Teaching Plan

Download MGC bulletin 52  (september 2015), MGC bulletin 51 (September 2014),  MGC bulletin 50 (April 2014),

Website of Leiden University on teaching for PhD students: English or Dutch. [Courses on Research management; Career counseling; Academic writing; Writing grants, proposals and beyond; Faster reading and Memory-improvement; Creative thinking; Academic presentation / Presentation of academic work; Orientation in policymaking; Orientation on Management]


The MGC Institutes

Het MGC secretariaat is gevestigd op

de afdeling Humane Genetica, LUMC, Leiden.

TEL 071-5269600; FAX 071-5268284  

Directie secretaris: Dr. M.J.M. Nivard 071-5269605  



De MGC instituten:

Instituut Celbiologie

Erasmus MC - Rotterdam

Postbus 2040, 3000 CA Rotterdam


hoofd: Prof.Dr. D. Huylebroeck (lid MGC bestuur)


Afd. Humane Genetica

Leiden Universitair Medisch Centrum

Postbus 9600, 2300 RC Leiden


hoofd: Prof.Dr. S.M. van der Maarel  (lid MGC bestuur)

Instituut Genetica

Erasmus MC - Rotterdam

Postbus 2040, 3000 CA Rotterdam


hoofd: Prof.Dr. J.H.J. Hoeijmakers (lid MGC bestuur)

Afd. Humane Genetica

Leids Universitair Medisch Centrum

Postbus 9600, 2300 RC Leiden


Prof.Dr. L.H.F. Mullenders (voorzitter MGC bestuur)

LACDR (Leiden/Amsterdam Center for Drug Research) - Toxicology group

Universiteit Leiden

P.O. Box 9502, 2300 RA Leiden


hoofd: Prof.Dr. B. van de Water (lid MGC bestuur)  

Instituut Klinische Genetica

Erasmus MC - Rotterdam

Postbus 2040, 3000 CA Rotterdam


hoofd: Prof.Dr. R.M.W. Hofstra (secretaris MGC bestuur)

Andere instituten/groepen binnen het MGC

Moleculaire Celbiologie (Prof. Dr. H.J. Tanke & Prof. Dr. A.K. Raap, Prof. Dr. J. Noordermeer & Dr. L. Fradkin, Prof. Dr. R. Hoeben, Prof. Dr. J.A. Maassen, Prof. Dr. P. ten Dijke)

Neurologie, groep neurogenetica, LUMC (Prof. Dr. R.A.C. Roos, Prof. Dr. J.J.G.M. Verschuuren, Prof. Dr. M.D. Ferrari)

Huid- en geslachtsziekten, groep erfelijke melanomen, LUMC (Prof. R. Willemze, Prof. Dr. W. Bergman, Dr. F. de Gruijl, Dr. N.A. Gruis)

Pathologie: moleculaire tumorpathologie, LUMC (Prof. Dr. P.C.W. Hogendoorn, Prof. J.V.M.G. Bovee, Prof. Dr. J. Morreau, Prof. Dr. P. Devilee)

Medische Statistiek, LUMC (Prof. Dr. T. Stijnen, Prof. Dr. P.E. Slagboom)

Anatomie en Embryologie, LUMC (Prof. Dr. C.L. Mummery)

Erasmus Optical Imaging Centre (OIC), Department of Pathology, Erasmus MC (Prof. Dr. A. B. Houtsmuller)

Kinderheelkunde, Ontwikkelingsbiologie groep, Erasmus MC (Prof. Dr. D. Tibboel)

Genetische Epidemiologie, Erasmus MC (Prof. Dr. C.M. van Duijn)

Afd. Ontwikkelingsbiologie, Erasmus MC (Prof. Dr. J. Gribnau)

Genetische Identificatie, Erasmus MC (Prof. Dr. M. Kayser)

Bioinformatica, Erasmus MC (Prof. Dr. P. van der Spek)

Biochemie, Erasmus MC (Prof. Dr. P. Verrijzer)

   [n.b. verbeteringen voor deze lijst gaarne doorgeven aan het secretariaat]




























Revised: November 17, 2015